Regulation of CD4 T-cell immunity by eukaryotic Elongation Factor 2 Kinase

Abstract CD4 T cells are a major source of inflammatory cytokines to manage the immune responses, and there is evidence showing that IL-17-secreting helper (Th17 cells), play critical role in autoimmune diseases. Eukaryotic Elongation Factor 2 Kinase (eEF2K) protein kinase negatively regulates elongation step synthesis. eEF2K vascular responses hypertension development, yet complete immunologic characterization eEF2K, particularly diseases, remains obscure. Defining eEF2K-mediated cell activities, including inflammation metabolism, will significantly enhance our knowledge toward goal improving health span. Here, we reported essential for survival proliferative capacity cells. deficient mice displayed higher metabolic profile increased production cytokines. By analyzing from wild type (WT) mice, revealed mitochondrial stress reactive oxygen species (ROS) through master transcription factor, STAT3. Depletion agitated Th17-related arthritis colitis. A STAT3 inhibitor, C188–9, attenuated Th17 cell-mediated colitis by reducing murine model received Our findings provide insights into regulation autoimmunity further investigations would help design novel strategies targeting eEF2K-based immunotherapy